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Corticosteroids are medications that relieve pain and inflammation. Corticosteroids are naturally produced in small amounts in all warm-blooded creatures, including people and pets. Pharmaceutical corticosteroids mimic natural steroids, but are in a much higher concentration. They are generally used for emergency rather than chronic treatment of painful conditions. Because corticosteroid drugs have serious side effects, they require a prescription, and your veterinarian may request periodic blood tests to confirm your pet's liver remains healthy. Some veterinarians recommend supplementing with SAMe (Denosyl) to protect the liver.
What are examples of corticosteroids used for pets?
Corticosteroid medications can be applied topically to the eye and skin for pain relief (as a corticosteroid cream), taken orally, or as a corticosteroid injection into the joints and muscles. Oral or injectible forms of prednisone, prednisolone, dexamethasone, and triamcinolone are used to treat pets with bone and joint pain. These medications require a prescription.
What pet health problems are helped with corticosteroids?
Corticosteroids affect every organ, and possibly every cell in the pet's body. They are used to control inflammation, allergic reactions, and pain. They can be used for emergency treatment when the pet's system is over-reacting and causing life threatening swelling, and for routine use to control pain, allergic symptoms, itching, and swelling. corticosteroids are routinely used to supplement pets whose adrenal glands aren't producing steroids; and they can be used to treat some forms of cancer.
| Corticosteroids (pain relief): for emergencies |
Bone and joint: Brain and nervous system: Digestive system:
Lungs:
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Circular skin rash Increased intracranial pressure Gastric dilatation and volvulus, endotoxic shock Acute respiratory distress syndrome, aspiration pneumonia |
| Corticosteroids: for all types of inflammation |
Bladder:
Bones, joints, and spine:
Brain and nervous system:
Eye:
Ears:
Immune system:
Liver:
Lungs and trachea:
Mouth, stomach, intestines:
Pancreas:
Skin:
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Feline lower urinary tract disease (flutd)
Osteoarthritis, rheumatoid arthritis, spondylosis deformans, hip and elbow dysplasia, dislocating knee cap (luxating patella), abnormal joint cartilage development (osteochondritis dissecans or OCD), spinal arthritis (spondylosis deformans), intervertebral disc disease
Meningitis, encephalitis, hydrocephalus, peripheral neuropathies, trigeminal neuritis
Anterior uveitis, conjunctivitis, keratitis
Otitis externa, otitis media
Lupus, pemphigus
Chronic active hepatitis, copper-induced hepatopathy
Chronic bronchitis, asthma, pneumonitis, collapsing trachea
Gingivitis eosinophilic gastroenteritis, colitis
Pancreatitis, exocrine pancreatic insufficiency
Juvenile cellulites |
corticosteroids: for allergic & immune-mediated reactions
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Blood:
Lungs: Skin:
Eye: Mouth, stomach, intestines:
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Autoimmune hemolytic anemia, immune-mediated thrombocytopenia
Asthma, allergic bronchitis
Flea allergy dermatitis, contact dermatitis, urticaria, atopy, eosinophilic ulcer, miliary dermatitis
Anterior uveitis, conjunctivitis, keratitis pneumonia
Food allergy |
Corticosteroids, the good and the bad
Corticosteroids are powerful healing drugs. Like any powerful drug they can also cause harm. Some corticosteroid side effects include stomach ulcers, delayed wound healing, thyroid hormone suppression, immune suppression so that the body doesn't fight infection well, high blood sugar, and swollen liver. Many pets will drink more and urinate more (polydipsia and polyuria or PUPD). Some pets will have an increased appetite, and some will have fluid retention (edema).
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With long-term use, bones may weaken (osteoporosis), skin may thin and hair may fall out (alopecia). If given to pregnant pets, fetuses can be malformed, or they may be miscarried. corticosteroids can affect a pet's sense of wellbeing. Some pets feel happy, and others become irritable. |
Making corticosteroid use safer
3. Start the corticosteroid before the problem becomes severe rather than waiting until it is severe.
4. Provide plenty of water because corticosteroids often increase thirst. Provide for more frequent potty breaks.
5. Weigh the pet periodically, and note changes in appetite. Keep your veterinarian informed of these changes.
6. Have blood and urine tests as requested by your veterinarian.
7. Because pets on steroids can develop stomach and intestinal ulcers, check the stool for the presence of blood. Blood from an ulcer passes through the gut along with food and is digested into a black, tarry substance. Finding a blackish stool is reason to stop medicating. Notify your veterinarian immediately.
8. Never give corticosteroids without your veterinarian's advice.
Corticosteroid Strengths:
Short-acting (less than 12 hours duration)
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Cortisone* Hydrocortisone* Fludrocortisone** |
| Intermediate-acting (from 12-36 hours duration)
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Prednisone* Prednisolone* Methylprednisolone* Triamcinolone* |
| Long-acting (from 36-72 hours duration)
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Paramethasone** Betamethasone*** Dexamethasone*** Flumethasone*** |
* Low potency ** Medium potency *** High potency
What's the difference between Prednisone and Prednisolone?
Prednisolone does not have to be converted by the liver to an active molecule, but prednisone does. For pets with liver failure, prednisolone is preferred.
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PrednisonePrednisoloneTriaminolone |
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Emergencies
Inflammation
Allergic reactions
Cancer |
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Control inflammation
Control allergic reactions
Reduce pain |
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Stomach ulcers
Delayed wound healing
Thyroid hormone suppression
Immune suppression
increased appetiteFluid retention
Weak bones
Thinning hair/hair loss |
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